Vaginal Candidiasis

an incomprehensible challenge

Abstract

Recurrent infection of Candida albicans in the vaginal rnucous was dealt with highlighting the mechanismi; of interaction bctween t he fungus and the vaginal epithelium, emphasizing the immunological aspects which control fungal proliferation. The role of cell immunity, which is a process of balance between agent and host, is pointed out stressing the lmportance, through Th₁ of an immune response, which releases cytokines (gamma interferon, interleukin- 1 and 12). On theother hand, a Th₁ way, which relesses interleukin- 4 , 5 and 10 leading to antibodies produclion, will play a limited role regarding the defense of the mucous against this agent. Pathophysiogenic aspects, involving an imrnune response linked to individual allergic processes and those due to interaction with a sexual partner, are also dealt with. Diagnosis, the main means towards adequate trcatmcnt is focused on, using a praclical approach, stressing the use of simple exams, but also commenting on how helpful sophisticated techniques such as PCR can be useful for certain cases. The treatment for the acute stage and for maintenance is to avoid recurrence, stressing the necessity of tak.ing altitudes that not only fight the fungus but which also give priority to the identification and elimination of possible allergens.