Immunohistochemistry markers for lesions preceding HPV-induced cervical cancer

the role of tumoral suppression P16INK4A protein P16INK4A

Authors

  • José Eleutério Junior
  • Paulo C Giraldo

Keywords:

p16INK4a, HPV, scamous intra-epitelial lesions, cervical cancer, sexually transmitted disease

Abstract

The HPV and cervical squamous intra-epithelial neoplasia relation is established. The mechanisms used by the virus which causes the transformationof the squamous intra-epithelial are associated to the E6 and E7 HPV genes The E7 gene has an important role inducing the host cell changes which are related to the retinoblastoma protein and E2F transcription factor. Whenthe phenomenon induced by the E7 occurs, there is the expression of the p16INK4aprotein which can be detected by immunohistochemistry. Recentstudies have shown the importance of the use of the p16INK4aas a marker for cellular transformation induced by HPV and its clinical use in practice,mainly helping in the diagnosis of high grade squamous intra-epithelial lesions in biopsies. This revision intends to provide to the reader an update tothe understanding of how cellular markers can contribute to improve the differential diagnosis of the squamous intra-epithelial neoplasia and its prog-nosis.

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Author Biographies

José Eleutério Junior

Aluno de pós-graduação nível de Doutorado do Departamento de Tocoginecolo-gia/FCM da Universidade Estadual de Campinas. 

Paulo C Giraldo

Professor Associado, Livre-Docente do Departamento de Tocoginecologia/FCM da Universidade Estadual de Campinas. 

Published

2006-03-18

How to Cite

1.
Eleutério Junior J, Giraldo PC. Immunohistochemistry markers for lesions preceding HPV-induced cervical cancer: the role of tumoral suppression P16INK4A protein P16INK4A. DST [Internet]. 2006 Mar. 18 [cited 2024 Nov. 13];18(1):62-5. Available from: https://bjstd.org/revista/article/view/614

Issue

Section

Review Article