Human papillomavirus infection in multiple sites

Authors

  • Silvia Maria Baeta Cavalcanti Universidade Federal Fluminense
  • Thaissa Isaias Cordeiro Universidade Federal Fluminense
  • Fernanda Nahoum Carestiato Universidade Federal Fluminense
  • Tegnus Vinicius Depes de Gouvêa

Keywords:

papillomavirus infections, polymerase chain reaction, anus

Abstract

Introduction: Studies concerning human papillomavirus natural history have been focused on cervical infection and disease, but have scarcely described anal infections, especially in clinically health population. Hence, knowledge on HPV natural history is recently being investigated although viral maintenance in hosts is poorly understood. Detection on diverse, extragenital sites may add in the elucidation of infection-dissemination-reinfection cycle reported on the human genital tract. Besides that, it is evident the importance of an adequate screening of the viruses for appropriate diagnosis, mainly in the first steps of the neoplasia in order to provide a better prognosis. Our results pointed out HPV prevalence rates in genital lesions of 87% (80/92) and of 47.8% (44/92) for anal samples. We pointed out that this high prevalence is due to clinically detected lesions, that contributes to the risk of extragenital infections, mainly by host auto-inoculation. Despite the difference in samples size, we did not find statistical relevant differences related with genera (men 85.1% and women 92%; p>0.05), corroborating the idea of no tropism differences by sex. Nevertheless, for anal samples, statistically significant differences were found between men and women (68% of anal HPV infection in women against 40.3% in men (p=0.038). These results reveal that female anal infections are more frequent than in men, suggesting that infection by autoinoculation occurs and can render this site as an HPV reservoir, occasionally becoming clinical lesions. Hormonal profile, sexual behavior and differences among body sites can explain these differences here described. Our study is a preliminary evaluation of HPV infection in human multiple sites.

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Author Biographies

Silvia Maria Baeta Cavalcanti, Universidade Federal Fluminense

Department of Microbiology and Parasitology, Universidade Federal Fluminense (UFF) – Niterói (RJ), Brazil.

Thaissa Isaias Cordeiro, Universidade Federal Fluminense

Department of Microbiology and Parasitology, Universidade Federal Fluminense (UFF) – Niterói (RJ), Brazil.

Fernanda Nahoum Carestiato, Universidade Federal Fluminense

Department of Microbiology and Parasitology, Universidade Federal Fluminense (UFF) – Niterói (RJ), Brazil.

Tegnus Vinicius Depes de Gouvêa

Sector of Sexually Transmitted Diseases, UFF – Niterói (RJ), Brazil

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Published

2022-08-09

How to Cite

Cavalcanti, S. M. B., Cordeiro, T. I., Carestiato, F. N., & Gouvêa, T. V. D. de. (2022). Human papillomavirus infection in multiple sites. Brazilian Journal of Sexually Transmitted Diseases, 26(1-4), 42–46. Retrieved from https://bjstd.org/revista/article/view/636

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Section

Nota Prévia