Potential antiviral activity of Plexaurella regia on the replication of herpes simplex virus type 1

Authors

  • Izabel Christina Nunes de Palmer Paixão Universidade Federal Fluminense
  • Viveca Giongo Universidade Federal Fluminense
  • Camilly Pestana Pires de Mello Universidade Federal Fluminense
  • Felipe Mateini Universidade Federal Fluminense
  • Juliana Barbosa
  • Jussara Pinheiro Barbosa Universidade Federal do Rio de Janeiro
  • Beatriz Grosso Fleury Universidade Federal do Rio de Janeiro
  • Clovis Barreira e Castro
  • Angelo da Cunha Pinto Universidade Federal do Rio de Janeiro

Keywords:

natural products, antivirals, drug resistance, HSV-1

Abstract

Introduction: Latency and resistance of acyclovir-resistant strains of Herpes simplex virus type 1 (HSV-1) have been associated with serious sequelae in immunocompromised individuals, such as AIDS patients. Consequently, the search for new substances with anti-HSV activity is both necessary and urgent. Objective: To investigate whether extracts obtained from Plexaurella spp can be used in preclinical studies of drugs against herpes simplex virus type 1. Methods: Cell viability and inhibitory drug concentrations as screening tests were used to investigate ethyl acetate and dichloromethane extracts from Plexaurella spp as antivirals. Results: The results of viability assays demonstrated that extracts from Plexaurella regia and Plexaurella grandiflora showed less cytotoxicity, but only Plexaurella regia reached a very expressive CC50 value. In antiviral assays, Plexaurella regia showed an even more significant result of effective concentration (EC50) and therapeutic index (<2.5 μg/mL and 51.6 μg/mL, respectively) compared with acyclovir (ACV). Conclusion: These results demonstrated that extracts from corals have anti-herpetic activities and could contribute towards new strategies to stop the increasing incidence of resistance in herpes-related diseases.

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Author Biographies

Izabel Christina Nunes de Palmer Paixão, Universidade Federal Fluminense

Department of Cell and Molecular Biology, Institute of Biology, Universidade Federal Fluminense (UFF) – Niterói (RJ), Brazil

Viveca Giongo, Universidade Federal Fluminense

Department of Cell and Molecular Biology, Institute of Biology, Universidade Federal Fluminense (UFF) – Niterói (RJ), Brazil

Camilly Pestana Pires de Mello, Universidade Federal Fluminense

Department of Cell and Molecular Biology, Institute of Biology, Universidade Federal Fluminense (UFF) – Niterói (RJ), Brazil

Felipe Mateini, Universidade Federal Fluminense

Department of Cell and Molecular Biology, Institute of Biology, Universidade Federal Fluminense (UFF) – Niterói (RJ), Brazil

Juliana Barbosa

Department of Marine Biology, Institute of Biology, UFF – Niterói (RJ), Brazil.

Jussara Pinheiro Barbosa, Universidade Federal do Rio de Janeiro

Department of Chemistry, Institute of Chemistry, Universidade Federal do Rio de Janeiro – Rio de Janeiro (RJ), Brazil

Beatriz Grosso Fleury, Universidade Federal do Rio de Janeiro

Department of Chemistry, Institute of Chemistry, Universidade Federal do Rio de Janeiro – Rio de Janeiro (RJ), Brazil.

Clovis Barreira e Castro

Department of Invertebrates, National Museum, UFRJ – Rio de Janeiro (RJ), Brazil.

Angelo da Cunha Pinto, Universidade Federal do Rio de Janeiro

Department of Chemistry, Institute of Chemistry, Universidade Federal do Rio de Janeiro – Rio de Janeiro (RJ), Brazil.

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Published

2022-04-20

How to Cite

1.
Paixão ICN de P, Giongo V, Mello CPP de, Mateini F, Barbosa J, Barbosa JP, et al. Potential antiviral activity of Plexaurella regia on the replication of herpes simplex virus type 1. DST [Internet]. 2022 Apr. 20 [cited 2024 Nov. 23];28(1):11-5. Available from: https://bjstd.org/revista/article/view/745

Issue

Vol. 28 No. 1 (2016)

Section

Original Article