Manipulation of autophagy by sexually transmitted infections

new opportunities for intervention

Authors

  • Aikaterini Athanasiou
  • Julie Leizer
  • Evelyn Minis
  • Lara M. Linhares
  • Steven S. Witkin

Abstract

Autophagy, from the Greek words meaning “self‑eating”, is an evolutionarily conserved multistep process preserved amongst all eukaryotes to maintain cellular homeostasis(1). It is an intracellular, catabolic process whereby dysfunctional organelles such as mitochondria and inflammasomes, aggregated or unneeded proteins as well as intracellular bacteria and viruses and their components are degraded(2,3). The entities marked for destruction become surrounded by a double membrane structure called an autophagosome. The autophagosome fuses with a lysosome and the sequestered components are catabolized by lysosomal enzymes(4‑6). The resulting amino acids, fatty acids, carbohydrates and nucleic acid components are returned to the cytoplasm to provide additional nutrients for various metabolic processes. [...]

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Author Biographies

Aikaterini Athanasiou

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine.

Julie Leizer

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine.

Evelyn Minis

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine.

Lara M. Linhares

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, and Department of Gynecology and Obstetrics, University of Sao Paulo Medical School.

Steven S. Witkin

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine.

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Published

2017-01-08

How to Cite

1.
Athanasiou A, Leizer J, Minis E, Linhares LM, Witkin SS. Manipulation of autophagy by sexually transmitted infections: new opportunities for intervention. DST [Internet]. 2017 Jan. 8 [cited 2024 Dec. 10];29(1):5-7. Available from: https://bjstd.org/revista/article/view/790

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Section

Editorial