Pilot evaluation of a rapid immunochromatographic test for the diagnosis of gestational syphilis

Authors

  • Mauro Cunha Ramos
  • Luiz Eduardo Bernardi
  • Marcia Susana Nunes da Silva
  • Maria Lucia Rosa Rossetti

Keywords:

syphilis, diagnosis, pregnancy, congenital syphilis

Abstract

Introduction: Gestational syphilis is a global public health problem and one of the most common causes of adverse effects during pregnancy due to absence or inadequacy of treatment. Establishing a diagnosis of syphilis during prenatal care prevents the transmission of Treponema pallidum to the child. Objective: The objective of this study was to evaluate the performance of OL Syphilis (OrangeLife, Brazil), a rapid immunochromatographic test for gestational syphilis diagnosis. Methods: A total of 185 pregnant women in prenatal care were evaluated by OL Syphilis. The results were compared by traditional methods: Venereal Disease Research Laboratory and Rapid Plasma Reagin (VDRL and RPR) for screening and fluorescent treponemal antibody absorption test (FTA-Abs) for confirmation. Results: The prevalence of syphilis in this population was 6.49% (95%CI 3.40 to 11.06%). Rapid Test (RT) sensitivity was 91.67% (95%CI 61.52 to 99.79%) and specificity was 100% (95%CI 97.89 to 100%). Positive predictive value was 100% (95%CI 71.51 to 100%) and Negative predictive value was 99.43% (95%CI 96.84 to 100%). The agreement measured by Kappa coefficient was 0.954 (95%CI 0.863 to 1.000). Conclusion: The OL Syphilis test could be used for screening pregnant women, thus providing rapid diagnosis, increasing the probability of diagnosis and timely treatment, and preventing the devastating consequences of congenital syphilis.

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Author Biographies

Mauro Cunha Ramos

Municipal Secretariat of Porto Alegre – Porto Alegre (RS), Brazil. Specialization in Dermatology, Fundação Federal de Ciências Médicas de Porto Alegre – Porto Alegre (RS), Brazil.

Luiz Eduardo Bernardi

Postgradaute program in Cell and Molecular Biology, Universidade Luterana do Brasil (ULBRA) – Canoas (RS), Brazil. Municipal Secretariat of São João – São João (PR), Brazil.

Marcia Susana Nunes da Silva

Postgradaute program in Cell and Molecular Biology, Universidade Luterana do Brasil (ULBRA) – Canoas (RS), Brazil.

Maria Lucia Rosa Rossetti

Postgradaute program in Cell and Molecular Biology, Universidade Luterana do Brasil (ULBRA) – Canoas (RS), Brazil. Center for Scientific and Technological Development, Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS) – Porto Alegre (RS), Brazil.

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Published

2017-03-05

How to Cite

Ramos, M. C., Bernardi, L. E., Silva, M. S. N. da, & Rossetti, M. L. R. (2017). Pilot evaluation of a rapid immunochromatographic test for the diagnosis of gestational syphilis. Brazilian Journal of Sexually Transmitted Diseases, 29(3), 106–109. Retrieved from https://bjstd.org/revista/article/view/806

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Original Article