Mixed infection and two different resistance profiles of treponema pallidum to macrolides identified in some clinical specimens of the same patient

Authors

  • Paola Brandão Ferreira de Oliveira Instituto Oswaldo Cruz
  • Márcia Quinhones Pires Lopes Instituto Oswaldo Cruz
  • Marize Quinhones Pires Instituto Oswaldo Cruz
  • Harrison Magdinier Gomes Instituto Oswaldo Cruz
  • Leonardo Barraza Lora
  • José Augusto Nery
  • Rosana Rocha Barros
  • Philip Noel Suffys Instituto Oswaldo Cruz

Keywords:

syphilis, drug resistance, DNA sequencing

Abstract

Syphilis represents a global public health problem. The resistance of Treponema pallidum to macrolides is related to the mutation in the 23S rRNA gene (A2058G). We reported a case of secondary syphilis in a 52 year old man presenting two profiles: the first one of susceptibility, and the other one of resistance, when we analyzed the 23S rRNA gene sequence from two different clinical specimens of the same infectious episode. DNA from T. pallidum from skin biopsy presented resistance profile, whereas T. pallidum DNA from blood presented a profile of susceptibility to macrolides. These results suggest it was mixed infection or reinfection.

Downloads

Download data is not yet available.

Author Biographies

Paola Brandão Ferreira de Oliveira, Instituto Oswaldo Cruz

Laboratório de Biologia Molecular Aplicada à Micobactérias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz – Rio de Janeiro (RJ), Brasil.

Márcia Quinhones Pires Lopes, Instituto Oswaldo Cruz

Laboratório de Biologia Molecular Aplicada à Micobactérias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz – Rio de Janeiro (RJ), Brasil.

Marize Quinhones Pires, Instituto Oswaldo Cruz

Laboratório de Biologia Molecular Aplicada à Micobactérias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz – Rio de Janeiro (RJ), Brasil.

Harrison Magdinier Gomes, Instituto Oswaldo Cruz

Laboratório de Biologia Molecular Aplicada à Micobactérias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz – Rio de Janeiro (RJ), Brasil.

Leonardo Barraza Lora

Instituto de Dermatologia Professor Rubem David Azulay – Rio de Janeiro (RJ), Brasil

José Augusto Nery

Instituto de Dermatologia Professor Rubem David Azulay – Rio de Janeiro (RJ), Brasil

Rosana Rocha Barros

Setor de Microbiologia e Parasitologia Aplicadas, Universidade Federal Fluminense – Rio de Janeiro (RJ), Brasil.

Philip Noel Suffys, Instituto Oswaldo Cruz

Laboratório de Biologia Molecular Aplicada à Micobactérias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz – Rio de Janeiro (RJ), Brasil.

Downloads

Published

2018-03-10

How to Cite

1.
Oliveira PBF de, Lopes MQP, Pires MQ, Gomes HM, Lora LB, Nery JA, et al. Mixed infection and two different resistance profiles of treponema pallidum to macrolides identified in some clinical specimens of the same patient. DST [Internet]. 2018 Mar. 10 [cited 2024 Dec. 21];30(1):25-9. Available from: https://bjstd.org/revista/article/view/820

Issue

Vol. 30 No. 1 (2018)

Section

Case Report