chlamydia trachomatis and HPV coinfections in women with condiloma acuminata

Authors

  • Larissa D. Marcolino
  • Jossimara Polettini
  • Andréa R. Tristão
  • Mariângela Esther A. Marques
  • João Manuel G. Candeias
  • Rodrigo Alessandro R. Vela
  • Márcia G. Silva Silva

Keywords:

human papillomavirus, Chlamydia trachomatis, condyloma acuminata, STD

Abstract

Introduction: Chlamydia trachomatis is worldwide recognized as one of the most prevalent sexually transmitted diseases (STD) of bacterial origin, whereas genital Human Papillomavirus (HPV) infection is one of the most important STD caused by virus. Objective: evaluate the coinfection rate of C. trachomatis and HPV in women with condyloma acuminata. Methods: thirty women were included in the study based on clinical and histopa­ thological diagnosis of condyloma acuminata in vulvar, vaginal or perianal region. The excised lesions were divided into two halves, one was submit­ ted to a histopathological exam and the other to DNA extraction. C. trachomatis was detected by PCR using CTP1 and CTP2 primers and the HPV DNA was detected by PCR and subsequent typed by PCR with HPV specific primers. Results: the HPV DNA positivity was 100% in all samples. HPV type 6/11 was found in 33.3% of the samples, type 18 in 6.7%, and we also found infection with multiple HPV types in 56.7% of HPV induced lesions, and only one sample (3,3%) was not genotyped. The C. trachomatis positivity in cervical secretions of women with condyloma acuminata was 33.3%. Conclusion: the coinfection rate of C. trachomatis and HPV in women with condyloma acuminata is high and the screen and treat strate­ gy for chlamydial infection should be incorporated to gynecology routine care in these patients.

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Author Biographies

Larissa D. Marcolino

Graduada do Curso de Ciências Biológicas - Modalidade Médica do Instituto de Biociências de Botucatu - UNESP - Botucatu (SP) - Brasil.

Jossimara Polettini

Doutoranda do Programa de Pós-Graduação em Patologia da Faculdade de Medicina de Botucatu - UNESP - Botucatu (SP) - Brasil.

Andréa R. Tristão

Doutora pelo Programa de Pós-Graduação em Ginecologia, Obstetrícia e Mastologia da Faculdade de Medicina de Botucatu - UNESP - Botucatu (SP) - Brasil.

Mariângela Esther A. Marques

Professora Adjunta do Departamento de Patologia da Faculdade de Medicina de Botucatu - UNESP - Botucatu (SP) - Brasil.

João Manuel G. Candeias

Professor Assistente Doutor do Departamento de Microbiologia e Imunologia do Instituto de Biociências de Botucatu - UNESP - Botucatu (SP) - Brasil.

Rodrigo Alessandro R. Vela

Mestre pelo Programa de Pós-Graduação em Doenças Tropicais da Faculdade de Medicina de Botucatu - UNESP - Botucatu (SP) - Brasil.

Márcia G. Silva Silva

Professora Assistente Doutora do Departamento de Patologia da Faculdade de Medicina de Botucatu - UNESP - Botucatu (SP) - Brasil. Trabalho desenvolvido no Departamento de Patologia - Faculdade de Medicina de Botucatu. UNESP

Published

2008-04-23

How to Cite

1.
Marcolino LD, Polettini J, Tristão AR, Marques MEA, Candeias JMG, Vela RAR, et al. chlamydia trachomatis and HPV coinfections in women with condiloma acuminata. DST [Internet]. 2008 Apr. 23 [cited 2024 Mar. 29];20(2):87-92. Available from: https://bjstd.org/revista/article/view/929

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Original Article