The role of p16 and DAPK genes in cell cycle control and in the pathways of vulvar carcinogenesis

Authors

  • Susana Cristina Aidé Viviani Fialho Universidade Federal do Rio de Janeiro - UFRJ
  • Isabel Cristina C. Vai Universidade Federal do Rio de Janeiro - UFRJ
  • Gutemberg Almeida Universidade Federal do Rio de Janeiro - UFRJ
  • Fernanda Lattario Universidade Federal do Rio de Janeiro - UFRJ
  • Maria da Gloria C. Carvalho Universidade Federal do Rio de Janeiro - UFRJ

Keywords:

vulvar cancer, HPV, lichen sclerosus, p 16 gene, DAPK gene, STD

Abstract

Vulvar cancer is the fourth commonest kind of cancer in women and it represents 4.8% of cancers in the lower genital tract squamous cell carcinoma is responsible for 80-90% of all vulvar cancers. Squamous cell carcinoma and it’s premalignant lesions seem to develop in two distinct pathways, based on etiological and histopathological characteristics, thus forming a heterogeneous etiology. Whereas one of the pathways is related to HPV infection, the other is related to epithelial disorders such as: lichen sclerousus and epithelial hyperplasia. HPV is an important contributing factor of neoplasia in the lower genital tract. It is found in 90% of cervical cancers and in 30-40 % of vulvar cancers. The most prevalent kind is 16, followed by 18, 45, 31, and 33. The study of genetic and epigenetic alterations by means of methylation and genic immunoexpression has demonstrated great versatility to the monitoring of patients with cancer, which boosts researches of diagnostic and therapeutic methods for cancer. This update intends to demonstrate the role of pl6 and DAPK genes as well as the recent researches regarding the expression of these genes in the pathways of vulvar carcinogenesis.

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Author Biographies

Susana Cristina Aidé Viviani Fialho, Universidade Federal do Rio de Janeiro - UFRJ

Instituto de Ginecologia, Universidade Federal do Rio de Janeiro - UFRJ.

Isabel Cristina C. Vai, Universidade Federal do Rio de Janeiro - UFRJ

Instituto de Ginecologia, Universidade Federal do Rio de Janeiro - UFRJ.

Gutemberg Almeida, Universidade Federal do Rio de Janeiro - UFRJ

Instituto de Ginecologia, Universidade Federal do Rio de Janeiro - UFRJ.

Fernanda Lattario, Universidade Federal do Rio de Janeiro - UFRJ

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro - UFRJ.

Maria da Gloria C. Carvalho, Universidade Federal do Rio de Janeiro - UFRJ

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro - UFRJ.

Published

2008-12-01

How to Cite

1.
Fialho SCAV, Vai ICC, Almeida G, Lattario F, Carvalho M da GC. The role of p16 and DAPK genes in cell cycle control and in the pathways of vulvar carcinogenesis. DST [Internet]. 2008 Dec. 1 [cited 2024 Nov. 8];20(3-4):204-11. Available from: https://bjstd.org/revista/article/view/949

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Section

Original Article