Infecção pelo Papilomavírus Humano em regiões orais e anogenitais

prevalência e taxa de concordância

Authors

  • Thaissa Isaias Cordeiro
  • Silvia Maria Baeta Cavalcanti
  • Katia Cristina da Silva
  • Willker Menezes da Rocha
  • Daniele Ceperuelo Lisboa
  • Mauro Romero Leal Passos
  • Tegnus Depes de Gouvea
  • Charbell Miguel Kury

Keywords:

papillomaviridae, wounds and injuries, genitalia

Abstract

Introduction: HPV infection causes cancer at several anatomical sites. However, the infection’s natural history in non-cervical sites is understudied. Objective: To evaluate oral and anogenital HPV infections, correlating HPV prevalence rates and genotypes with site of infection and risk factors. Methods: In the present study, 351 samples from oral, genital, and anal sites of 117 patients were investigated by using PCR MY09/11 detection, followed by genotyping with RFLP. Results: HPV DNA prevalence was 89.7% (105/117) in genital lesions, 53.8% (63/117) in oral samples, and 58.9% (69/117) in anal samples. Regarding the risk factors associated with HPV in genital lesions, statistically significant rates for oral (p=0.039) and anal sex practices (p=0.0000012) were found. For oral samples, a relevant correlation concerning oral contraceptive use (p=0.039), tobacco smoking (p=0.036), and alcohol use (p=0.0075) were observed; whereas in anal samples, higher risk for HPV infection in patients who reported non-exclusive sexual partners (p=0.013) were found. The presence of viral DNA in all the three sites concurrently was observed in 36.8% of the cases (43/117). Among them, 18% (21/117) presented concordant HPV genotypes, diverging from the literature, and thus corroborating that there is still much to learn about HPV natural history, since different biological behaviors are expected within different populations. Differences in anatomy and physiology of the studied sites can determine different prevalence rates of infection by diverse genotypes. Conclusion: Due to the high prevalence of HPV DNA in extragenital sites, further studies are required to define aspects of HPV natural history among different human anatomical sites.

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Author Biographies

Thaissa Isaias Cordeiro

Department of Microbiology and Parasitology, Universidade Federal Fluminense – Niterói (RJ), Brazil.

Silvia Maria Baeta Cavalcanti

Department of Microbiology and Parasitology, Universidade Federal Fluminense – Niterói (RJ), Brazil

Katia Cristina da Silva

Department of Microbiology and Parasitology, Universidade Federal Fluminense – Niterói (RJ), Brazil

Willker Menezes da Rocha

Department of Microbiology and Parasitology, Universidade Federal Fluminense – Niterói (RJ), Brazil

Daniele Ceperuelo Lisboa

Department of Microbiology and Parasitology, Universidade Federal Fluminense – Niterói (RJ), Brazil

Mauro Romero Leal Passos

Sector of Sexually Transmitted Diseases, Universidade Federal Fluminense – Niterói (RJ), Brazil.

Tegnus Depes de Gouvea

Sector of Sexually Transmitted Diseases, Universidade Federal Fluminense – Niterói (RJ), Brazil.

Charbell Miguel Kury

Medical School of Campos dos Goytacazes – Campos dos Goytacazes (RJ), Brazil

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Published

2022-12-05

How to Cite

1.
Cordeiro TI, Cavalcanti SMB, Silva KC da, Rocha WM da, Lisboa DC, Passos MRL, et al. Infecção pelo Papilomavírus Humano em regiões orais e anogenitais: prevalência e taxa de concordância. DST [Internet]. 2022 Dec. 5 [cited 2024 Mar. 28];33. Available from: https://bjstd.org/revista/article/view/1132

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Section

Original Article