Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency

Authors

  • Karinne Cisne Fernandes Rebouças
  • José Eleutério Junior
  • Renata Mírian Nunes Eleutério
  • Kathiane Lustosa Augusto
  • Karla Maria Rêgo Leopoldo

Keywords:

papillomavirus infections, Papanicolaou test, vaginitis

Abstract

Introduction: The influence of vaginal infections on the natural history of human papillomavirus (HPV) is still unclear. Objective: To determine if patients with low-grade squamous intraepithelial lesions (LSILs) and HPV have more vulvovaginitis than patients with normal liquid-based cervical cytology who were negative for HPV. Methods: This is a cross-sectional study including 322 patients who underwent cervical exams. One hundred and sixty-seven of these patients had LSILs on cervical cytology and were simultaneously hybrid capture 2 (HC2)-positive for HPV, and the remaining 155 patients were negative for malignancies and intraepithelial lesions by cytology and HC2-negative for HPV. The prevalence of vaginal infections in both groups was compared using the χ2 test without Yates’ correction. Results: Among the patients with HPV and LSILs, the most common vaginal infection was vaginosis (8.98%) compared to candidiasis (12.9%) in the patients without LSILs and HPV. No significant differences were found in the prevalence of vaginosis between the two groups (p=0.53). Candidiasis was statistically more prevalent in patients without LSILs and HPV (p<0.001). Conclusion: An association was found between the presence of Candida and the absence of HPV. Although vaginosis was more frequent among patients with LSILs and HPV, it was not statistically significant.

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Author Biographies

Karinne Cisne Fernandes Rebouças

Resident Doctors at the Department of Gynecology and Obstetrics of the HGF – Fortaleza (CE), Brazil

José Eleutério Junior

Adjunct Professor at the Department of Maternal and Child Health of the Universidade Federal do Ceará (UFC) – Fortaleza (CE), Brazil.

Renata Mírian Nunes Eleutério

Biochemist at the Laboratório Professor Eleutério – Fortaleza (CE), Brazil

Kathiane Lustosa Augusto

Resident Doctors at the Department of Gynecology and Obstetrics of the HGF – Fortaleza (CE), Brazil

Karla Maria Rêgo Leopoldo

Resident Doctors at the Department of Gynecology and Obstetrics of the HGF – Fortaleza (CE), Brazil

Published

2022-04-20

How to Cite

Rebouças, K. C. F., Eleutério Junior, J., Eleutério, R. M. N., Augusto, K. L., & Leopoldo, K. M. R. (2022). Influence of human papillomavirus infection on the vaginal microbiome of women with immunocompetency. Brazilian Journal of Sexually Transmitted Diseases, 26(1-4), 5–9. Retrieved from https://bjstd.org/revista/article/view/640

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Section

Original Article