Systematic review of short-term prognostic factors of HIV patients admitted to an intensive care unit

Authors

  • Hugo Boechat Andrade Universidade Federal Fluminense
  • Cássia Righy Shinotsuka Oswaldo Cruz  Foundation (Fiocruz)
  • Ho Yeh Li University of São Paulo
  • Frederico Bruzzi de Carvalho Hospital Foundation of the State of Minas Gerais
  • Fernando Augusto Bozza Oswaldo Cruz Foundation (Fiocruz)
  • André Miguel Japiassú Oswaldo Cruz Foundation (Fiocruz)

Keywords:

HIV, AIDS, intensive care, prognostic factors, mortality

Abstract

Introduction: Knowing the short-term prognostic factors of critically ill HIV patients admitted to intensive care units (ICUs) in the era of combination antiretroviral therapy (cART) is important for the adoption of preventive measures and more effective treatment. To identify the most significant and common factors that determine short-term mortality, a systematic review of the relevant literature was carried out. Method: An internet search was conducted in three databases indexing scientific articles (PubMed, Scopus, and Web of Science) for studies investigating the prognostic factors of mortality or short-term survival (in ICUs and elsewhere in hospitals following ICU admission) of critically ill HIV-infected patients. The articles were selected according to pre-established criteria and evaluated independently by two researchers. The variables collected were author, year, study location, study type, number of patients with HIV, mortality, significant factors in simple logistic regression and multiple regression, main causes of admission, and inclusion criteria. Results: Twenty-six articles were selected for systematic review. Fifteen dealt with factors that determine mortality in the ICU, nine with hospital mortality following ICU admission, and two with both. Conclusions: Factors associated with the severity of acute disease, such as prognostic scores, albumin, and organ failure (shock and respiratory failure), seem to be more important as determinants of short-term mortality than those associated with HIV.

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Author Biographies

Hugo Boechat Andrade, Universidade Federal Fluminense

Intensive Care Unit of the Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation (Fiocruz) – Rio de Janeiro (RJ), Brazil. Sexually Transmitted Diseases Sector, Biomedical Institute, Fluminense Federal University (UFF) – Niterói (RJ), Brazil.

Cássia Righy Shinotsuka, Oswaldo Cruz  Foundation (Fiocruz)

Intensive Care Unit of the Evandro Chagas National Institute of InfectiousDisease, Oswaldo Cruz  Foundation (Fiocruz) – Rio de Janeiro (RJ), Brazil.

Ho Yeh Li, University of São Paulo

Intensive Care Unit for Infectious Diseases, Clinical Hospital of the School of Medicine, University of São Paulo (HC-USP) – São Paulo (SP), Brazil.

Frederico Bruzzi de Carvalho, Hospital Foundation of the State of Minas Gerais

Intensive Care Unit of the Eduardo de Menezes Hospital, Hospital Foundation of the State of Minas Gerais – Belo Horizonte (MG), Brazill.

Fernando Augusto Bozza, Oswaldo Cruz Foundation (Fiocruz)

Intensive Care Unit of the Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation (Fiocruz) – Rio de Janeiro (RJ), Brazil.

André Miguel Japiassú, Oswaldo Cruz Foundation (Fiocruz)

Intensive Care Unit of the Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation (Fiocruz) – Rio de Janeiro (RJ), Brazil.

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Published

2017-03-05

How to Cite

Andrade, H. B., Shinotsuka, C. R., Li, H. Y., Carvalho, F. B. de, Bozza, F. A., & Japiassú, A. M. (2017). Systematic review of short-term prognostic factors of HIV patients admitted to an intensive care unit. Brazilian Journal of Sexually Transmitted Diseases, 29(2), 36–43. Retrieved from https://bjstd.org/revista/article/view/799

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Original Article