O microbioma do tracto genital: colmatando o fosso entre a moda e realidade clínica

Autores

DOI:

https://doi.org/10.5327/DST-2177-8264-2024361396

Palavras-chave:

Microbiome, Vaginitis, Microbiota, Lactobacilli

Resumo

Nos últimos anos tem havido um enorme interesse no estudo do microbioma humano, não sendo o tracto genital exceção. No entanto, ainda não se conseguiu compreender totalmente o microbioma normal e anormal do trato genital. Apesar do conhecimento crescente, o diagnóstico das vaginites continua a ser maioritariamente empírico e muitas intervenções, como a utilização de probióticos, não são sustentadas por evidência de qualidade.

Downloads

Não há dados estatísticos.

Referências

Kidd C, Hayden BY. The psychology and neuroscience of curiosity. Neuron. 2015;88(3):449-60. https://doi.org/10.1016/j.neuron.2015.09.010

zur Hausen H, de Villiers EM, Gissmann L. Papillomavirus infections and human genital cancer. Gynecol Oncol. 1981;12(2 Pt 2):S124-8. https://doi.org/10.1016/0090-8258(81)90067-6

Lane N. The unseen world: reflections on Leeuwenhoek (1677) 'Concerning little animals'. Philos Trans R Soc Lond B Biol Sci. 2015;370(1666):20140344. https://doi.org/10.1098/rstb.2014.0344

Donné A. Animalculi observed in purulent fluids and secretions of genital organs from Men and Women. CR Acad Sci. 1836;3(385).

Wilkinson JS. Some remarks upon the development of epiphytes.: with the description of a new vegetable formation found in connexion with the human uterus. The Lancet. 1849;54(1365):448-51. https://doi.org/10.1016/S0140-6736(00)63203-8

Döderlein A. Das scheidensekret und seine bedeutung für das puerperalfieber. Munique: Unikum; 2012.

Gardner HL, Dukes CD. Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified non-specific vaginitis. Am J Obstet Gynecol. 1955;69(5):962-76. PMID: 14361525.

Cibley LJ, Cibley LJ. Cytolytic vaginosis. Am J Obstet Gynecol. 1991;165(4 Pt 2):1245-9. https://doi.org/10.1016/s0002-9378(12)90736-x

Gardner HL. Desquamative inflammatory vaginitis: a newly defined entity. Am J Obstet Gynecol. 1968;102(8):1102-5. https://doi.org/10.1016/0002-9378(68)90399-2

Stockdale CK. A positive culture result for gardnerella is not diagnostic of bacterial vaginosis. J Low Genit Tract Dis. 2016;20(4):281-2. https://doi.org/10.1097/LGT.0000000000000237

Khairat R, Ball M, Chang CC, Bianucci R, Nerlich AG, Trautmann M, et al. First insights into the metagenome of Egyptian mummies using next-generation sequencing. J Appl Genet. 2013;54(3):309-25. https://doi.org/10.1007/s13353-013-0145-1

Azevedo S, Lima-Silva J, Vieira-Baptista P. Impact of the sampling site in the result of wet mount microscopy. J Low Genit Tract Dis. 2019;23(2):176-81. https://doi.org/10.1097/LGT.0000000000000467

Sobel JD. Automated microscopy and pH test for diagnosis of vaginitis – the end of empiricism? NPJ Digit Med. 2023;6(1):167. https://doi.org/10.1038/s41746-023-00850-7

Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A. 2011;108 Suppl 1(Suppl 1):4680-7. https://doi.org/10.1073/pnas.1002611107

Hillier SL, Austin M, Macio I, Meyn LA, Badway D, Beigi R. Diagnosis and treatment of vaginal discharge syndromes in community practice settings. Clin Infect Dis. 2021;72(9):1538-43. https://doi.org/10.1093/cid/ciaa260

Vieira-Baptista P, Stockdale CK, Sobel JD. International Society for the Study of Vulvovaginal Disease recommendations for the diagnosis and treatment of vaginitis. Lisbon: Admedic; 2023.

Mitra A, Gultekin M, Ellis LB, Bizzari N, Bowden S, Taumberger N, et al. Genital tract microbiota composition profiles and use of prebiotics and probiotics in gynaecological cancer prevention: review of the current evidence, the European Society of Gynaecological Oncology prevention committee statement. Lancet Microbe. 2023;S2666-5247(23)00257-4.

Lev-Sagie A, Goldman-Wohl D, Cohen Y, Dori-Bachash M, Leshem A, Mor U, et al. Vaginal microbiome transplantation in women with intractable bacterial vaginosis. Nat Med. 2019;25(10):1500-4. https://doi.org/10.1038/s41591-019-0600-6

Wrønding T, Vomstein K, Bosma EF, Mortensen B, Westh H, Heintz JE, et al. Antibiotic-free vaginal microbiota transplant with donor engraftment, dysbiosis resolution and live birth after recurrent pregnancy loss: a proof of concept case study. EClinicalMedicine. 2023;61:102070. https://doi.org/10.1016/j.eclinm.2023.102070

Committee Opinion No. 725: vaginal seeding. Obstet Gynecol. 2017;130(5):e274-e278. https://doi.org/10.1097/AOG.0000000000002402

Publicado

2024-01-09

Como Citar

1.
Vieira-Baptista P. O microbioma do tracto genital: colmatando o fosso entre a moda e realidade clínica. DST [Internet]. 9º de janeiro de 2024 [citado 10º de maio de 2024];36. Disponível em: https://bjstd.org/revista/article/view/1396

Edição

Seção

Editorial