The relationship between HIV status and clinical manifestations of urogenital infections in women during pregnancy: a scoping review
DOI:
https://doi.org/10.5327/DST-2177-8264-2023351384Keywords:
HIV, Signs and symptoms, Female urogenital diseases and pregnancy complications, Pregnant women, Sexually transmitted infectionsAbstract
Introduction: Maternal and child health are essential to public health, especially during pregnancy, where urogenital infections can affect mothers and fetuses. Sexually transmitted infections (STIs) increase obstetric risks and have complex connections with the human immunodeficiency virus — HIV. In Brazil, pregnant women with HIV are a growing concern, requiring focus and appropriate interventions. Objective: This study aimed to examine the clinical and epidemiological characteristics of urogenital infections in pregnant women with and without HIV and to assess whether there are notable differences between these groups. Methods: A scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses — Extension for Scoping Reviews (PRISMA-ScR) and Joanna Briggs Institute guidelines. Databases such as Medical Literature Analysis and Retrieval System Online (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), and Scientific Electronic Library Online (SciELO) were explored using relevant terms. Inclusion/exclusion criteria selected nine studies for analysis. A Population, Intervention, Comparison, Outcome, and Study Design (PICOS) approach directed the search. Results: Pregnant women with HIV had a high prevalence of STIs, including Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and bacterial vaginosis. HIV infection appears to influence the risk and severity of urogenital infections. Pregnancy increases the risk of STIs, regardless of HIV status. Male partners may also influence the presence of STIs in pregnant women, especially those with HIV. Conclusion: This study highlights the association between HIV status and urogenital infections in pregnant women, indicating the need for appropriate screening and care. Prevention and treatment of STIs in pregnant women are essential for maternal and child health, regardless of HIV status. An in-depth understanding of these issues can improve public policies, clinical practices, and preventive interventions that target the overall health of these vulnerable populations.
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Brasil. Ministério da Saúde. Secretaria de Atenção Primária à Saúde. Departamento de Ações Programáticas. Manual de gestação de alto risco. Brasília: Ministério da Saúde; 2022 [cited on 2023 July 10]. Available from: https://portaldeboaspraticas.iff.fiocruz.br/wp-content/uploads/2022/03/manual_gestacao_alto_risco.pdf
Warr AJ, Pintye J, Kinuthia J, Drake AL, Unger JA, McClelland RS, et al. Sexually transmitted infections during pregnancy and subsequent risk of stillbirth and infant mortality in Kenya: a prospective study. Sex Transm Infect. 2019;95(1):60-6. https://doi.org/10.1136/sextrans-2018-053597
Fuchs E, Dwiggins M, Lokken E, Unger JA, Eckert LO. Influence of sexually transmitted infections in pregnant adolescents on preterm birth and chorioamnionitis. Infect Dis Obstet Gynecol. 2020;2020:1908392. https://doi.org/10.1155/2020/1908392
Smolarczyk K, Mlynarczyk-Bonikowska B, Rudnicka E, Szukiewicz D, Meczekalski B, Smolarczyk R, et al. The impact of selected bacterial sexually transmitted diseases on pregnancy and female fertility. Int J Mol Sci. 2021;22(4):2170. https://doi.org/10.3390/ijms22042170
Waltmann A, McKinnish TR, Duncan JA. Nonviral sexually transmitted infections in pregnancy: current controversies and new challenges. Curr Opin Infect Dis. 2021;34(1):40-9. https://doi.org/10.1097/QCO.0000000000000702
Rowley J, Hoorn SV, Korenromp E, Low N, Unemo M, Abu-Raddad LJ, et al. Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016. Bull World Health Organ. 2019;97(8):548-562P. https://doi.org/10.2471/BLT.18.228486
Domingues CSB, Lannoy LH, Saraceni V, Cunha ARC, Pereira GFM. Brazilian Protocol for Sexually Transmitted Infections 2020: epidemiological surveillance. Rev Soc Bras Med Trop. 2021;54(suppl 1):e2020549. https://doi.org/10.1590/0037-8682-549-2020
Mwatelah R, McKinnon LR, Baxter C, Karim QA, Karim SSA. Mechanisms of sexually transmitted infection-induced inflammation in women: implications for HIV risk. J Int AIDS Soc. 2019;22 Suppl 6(Suppl Suppl 6):e25346. https://doi.org/10.1002/jia2.25346
Vaillant AAJ, Naik R. HIV-1 associated opportunistic infections. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2023.
Meng S, Tang Q, Xie Z, Wu N, Qin Y, Chen R, et al. Spectrum and mortality of opportunistic infections among HIV/AIDS patients in southwestern China. Eur J Clin Microbiol Infect Dis. 2023;42(1):113-20. https://doi.org/10.1007/s10096-022-04528-y
Dionne-Odom J, Khan MJ, Jauk VC, Szychowski J, Long DM, Wallace S, et al. HIV status and other risk factors for prevalent and incident sexually transmitted infection during pregnancy (2000-2014). Infect Dis Obstet Gynecol. 2019;2019:6584101. https://doi.org/10.1155/2019/6584101
Joshi S, Mane A, Muwonge R, Divate U, Padbidri V, Kulkarni V, et al. Prevalence and predictors of bacterial vaginosis in HIV-infected women in Maharashtra, India. Int J STD AIDS. 2020;31(6):541-52. https://doi.org/10.1177/0956462419878333
Silva CM, Alves RS, Santos TS, Bragagnollo GR, Tavares CM, Santos AAP. Epidemiological overview of HIV/AIDS in pregnant women from a state of northeastern Brazil. Rev Bras Enferm. 2018;71(suppl 1):568-76. https://doi.org/10.1590/0034-7167-2017-0495
Barifouse R. Por que o número de grávidas com HIV não para de crescer no Brasil? [Internet]. 2020 [cited on 2023 July 10]. Available from: https://www.ufpb.br/saehu/contents/noticias/por-que-o-numero-de-gravidas-com-hiv-nao-para-de-crescer-no-brasil-1
Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467-73. https://doi.org/10.7326/M18-0850
Peters MDJ, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. 2020;18(10):2119-26. https://doi.org/10.11124/JBIES-20-00167
Santos CMC, Pimenta CAM, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. 2007;15(3):508-11. https://doi.org/10.1590/S0104-11692007000300023
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev 2016;(5):210. https://doi.org/10.1186/s13643-016-0384-4
Chaponda EB, Bruce J, Michelo C, Chandramohan D, Chico RM. Assessment of syndromic management of curable sexually transmitted and reproductive tract infections among pregnant women: an observational cross-sectional study. BMC Pregnancy Childbirth. 2021;21(1):98. https://doi.org/10.1186/s12884-021-03573-3
Mudau M, Peters RP, De Vos L, Olivier DH, Davey DJ, Mkwanazi ES, et al. High prevalence of asymptomatic sexually transmitted infections among human immunodeficiency virus-infected pregnant women in a low-income South African community. Int J STD AIDS. 2018;29(4):324-33. https://doi.org/10.1177/0956462417724908
Medina-Marino A, Mudau M, Kojima N, Peters RP, Feucht UD, De Vos L, et al. Persistent Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africa. Int J STD AIDS. 2020;31(4):294-302. https://doi.org/10.1177/0956462419898612
Teasdale CA, Abrams EJ, Chiasson MA, Justman J, Blanchard K, Jones HE. Incidence of sexually transmitted infections during pregnancy. PLoS One. 2018;13(5):e0197696. https://doi.org/10.1371/journal.pone.0197696
Smullin CP, Green H, Peters R, Nyemba D, Qayiya Y, Myer L, et al. Prevalence and incidence of Mycoplasma genitalium in a cohort of HIV-infected and HIV-uninfected pregnant women in Cape Town, South Africa. Sex Transm Infect. 2020;96(7):501-8. https://doi.org/10.1136/sextrans-2019-054255
Price CM, Peters RPH, Steyn J, Mudau M, Olivier D, De Vos L, et al. Prevalence and detection of trichomonas vaginalis in HIV-infected pregnant women. Sex Transm Dis. 2018;45(5):332-6. https://doi.org/10.1097/OLQ.0000000000000756
Yeganeh N, Kreitchmann R, Leng M, Nielsen-Saines K, Gorbach PM, Klausner JD. Diagnosis and treatment of sexually transmitted infections in male partners of pregnant women in Brazil. Int J STD AIDS. 2021;32(13):1242-9. https://doi.org/10.1177/09564624211032759
Asres AW, Endalew MM, Mengistu SY. Prevalence and trends of sexually transmitted infections among pregnant women in Mizan Tepi University Teaching Hospital, Southwest Ethiopia: a cross-sectional study. Pan Afr Med J. 2022;42:111. https://doi.org/10.11604/pamj.2022.42.111.30871
Short CES, Quinlan RA, Wang X, Preda VG, Smith A, Marchesi JR, et al. Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration. Front Cell Infect Microbiol. 2021;11:750103. https://doi.org/10.3389/fcimb.2021.750103
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