Failure in syndromic management due to drug-resistant Mycoplasma genitalium in Florianópolis, South Brazil

Authors

  • Fernando Hartmann Barazzetti Universidade Federal de Santa Catarina, Health Sciences Center, Molecular Biology, Microbiology, and Serology Laboratory (Reference Laboratory for Brazilian Gonococcal Antimicrobial Surveillance Program) – Florianópolis (SC), Brazil. https://orcid.org/0000-0001-6409-3021
  • Marcos André Schörner Universidade Federal de Santa Catarina, Health Sciences Center, Molecular Biology, Microbiology, and Serology Laboratory (Reference Laboratory for Brazilian Gonococcal Antimicrobial Surveillance Program) – Florianópolis (SC), Brazil. https://orcid.org/0000-0002-7303-6050
  • Jhonatan Augusto Ribeiro Universidade Federal de Santa Catarina, Health Sciences Center, Molecular Biology, Microbiology, and Serology Laboratory (Reference Laboratory for Brazilian Gonococcal Antimicrobial Surveillance Program) – Florianópolis (SC), Brazil. https://orcid.org/0000-0002-9222-7530
  • Henrique Borges da Silva Grisard Universidade Federal de Santa Catarina, Health Sciences Center, Molecular Biology, Microbiology, and Serology Laboratory (Reference Laboratory for Brazilian Gonococcal Antimicrobial Surveillance Program) – Florianópolis (SC), Brazil. https://orcid.org/0000-0002-7902-9548
  • Jéssica Motta Martins Universidade Federal de Santa Catarina, Health Sciences Center, Molecular Biology, Microbiology, and Serology Laboratory (Reference Laboratory for Brazilian Gonococcal Antimicrobial Surveillance Program) – Florianópolis (SC), Brazil. https://orcid.org/0000-0002-8852-7813
  • Julia Kinetz Wachter Universidade Federal de Santa Catarina, Health Sciences Center, Molecular Biology, Microbiology, and Serology Laboratory (Reference Laboratory for Brazilian Gonococcal Antimicrobial Surveillance Program) – Florianópolis (SC), Brazil. https://orcid.org/0000-0003-1681-7712
  • Patrícia de Almeida Vanny Universidade Federal de Santa Catarina, Professor Polydoro Ernani de São Thiago Universitary Hospital – Florianópolis (SC), Brazil.
  • Maria Luiza Bazzo Universidade Federal de Santa Catarina, Health Sciences Center, Molecular Biology, Microbiology, and Serology Laboratory (Reference Laboratory for Brazilian Gonococcal Antimicrobial Surveillance Program) – Florianópolis (SC), Brazil. https://orcid.org/0000-0003-1292-0974

DOI:

https://doi.org/10.5327/DST-2177-8264-2024361423

Keywords:

Sexually transmitted diseases, Macrolides, Polymorphism, single nucleotide, Urethritis

Abstract

Introduction: Mycoplasma genitalium is a bacterium associated with sexually transmitted infections that can cause urethritis in men and complications
in women, including preterm birth. Increasing macrolide resistance in M. genitalium poses challenges to treatment efficacy. Objective: To present a case of treatment failure of urethritis caused by macrolide-resistant M. genitalium. Case report: This case report describes a 20-year-old man with persistent urethral symptoms despite azithromycin treatment, wherein M. genitalium harbored the A2058G mutation in the 23S rRNA. Subsequent treatment with moxifloxacin resolved symptoms and cleared M. genitalium. Conclusion: The study highlights the importance of resistance testing to guide antimicrobial therapy and emphasizes the need for updated treatment guidelines in Brazil.

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Published

2024-09-16

How to Cite

1.
Hartmann Barazzetti F, Schörner MA, Ribeiro JA, Grisard HB da S, Martins JM, Wachter JK, et al. Failure in syndromic management due to drug-resistant Mycoplasma genitalium in Florianópolis, South Brazil. DST [Internet]. 2024 Sep. 16 [cited 2024 Nov. 21];36. Available from: https://bjstd.org/revista/article/view/1423

Issue

Vol. 36 (2024)

Section

Case Report

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